Linda was raised in Anchorage, Alaska. She earned a BA from Whitman College in Walla Walla, WA and moved to Chile for 18 years where she attended the Vina del Mar Escuela de Bellas Artes.

Linda's maternal family is from Kodiak Island, Alaska. Her mother was born in the village of Karluk and her grandparents ran a small commercial salmon fishing boat off the coast of Kodiak and a restaurant called The Polar Bear Cafe. 

Linda is a registered Alutiiq Alaska Native and has tribal affiliation with the Alutiiq/Sugpiaq corporation, Koniag. Her work is part of the Alutiiq Museum's contemporary Alutiiq art collection and is featured in the First American Art Magazine, the Inuit Art Quarterly and Igaruacirpet, Our Way of Making Design, an Alutiiq design publication.

Infante Lyons has been painting and exhibiting her work for over 20 years. Her work has been shown in national and international exhibits and is part of the permanent collections of the Allen Memorial Art Museum, Oberlin, OH, Anchorage Museum at Rasmuson Center,  the Pratt Museum, the Alaska State Museum, the Alaska Contemporary Art Bank and the Museum of the North in Fairbanks, Alaska.

Lyons has received several grants and awards including a 2023 Bennett Prize finalist, a 2020 Joan Mitchell Foundation Painters and Sculptors Grant, a 2020 and 2016 Rasmuson Foundation Fellowship, a 2018 Native Arts and Cultures Foundation National Artist Fellowship, and in 2015, a Santa Fe Arts Institute and the Institute of American Indian Art Fellowship.

She currently lives in Anchorage with her husband, British artist Graham Dane.